Propolis & CAPE modulate breast cancer therapeutic targets

CAPE is effective in many models of human cancer, including breast cancer as we have previously shown. CAPE affects genes associated with tumor cell growth and survival, angiogenesis and chemoresistance.

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CAPE: A review on its anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects

Caffeic acid phenethyl ester (CAPE) is an important active component of honey bee propolis that possesses a plethora of biological activities. Propolis is used safely in traditional medicine as a dietary supplement for its therapeutic benefits. This review highlights the recently published data about CAPE bioavailability, anti-inflammatory, neuroprotective; hepatoprotective and cardioprotective activities.

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Topical application of propolis for diabetic foot ulcer healing

This feasibility study found that topical propolis is a well-tolerated therapy for wound healing and indicates for the first time that it may enhance wound closure in this setting when applied weekly to diabetic foot ulcers.

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Propolis - Properties, Applications & its Potential

Propolis is a honeybee product known for its biological and pharmacological properties for centuries. It has been extensively used in traditional medicine and also, because of its antibacterial, antiseptic, anti-inflammatory, and anesthetic activities, in complementary medicine. Propolis became subject of numerous studies developed and carried out all over the world in order to analyze its chemical composition as well as medicinal properties.

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Review - CAPE & Therapeutic Potentials

Caffeic acid phenethyl ester (CAPE) is a bioactive compound of propolis extract. The literature search elaborates that CAPE possesses antimicrobial, antioxidant, anti-inflammatory, and cytotoxic properties.

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Propolis supplementation leads to a lower level of glucose and cholesterol concentrations in aging

Positive influence of a natural product as propolis on antioxidant status and lipid peroxidation in senescent rats

Given the importance of oxidative stress associated to aging, it would be interesting to assess the effect of oral supplementation with antioxidant substances capable of diminishing oxidative aggression and free radicals generation associated to this condition.

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CAPE from propolis may help treat thrombosis

Caffeic acid phenethyl ester (CAPE) is a component of honeybee hives with various beneficial properties. Tissue factor (TF), the key trigger of thrombosis, is expressed in human endothelial cells. This study was designed to investigate whether CAPE modulates TF expression in human aortic endothelial cells (HAECs).

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How Propolis Works

Propolis expert James Fearnley summarises how propolis works - ten minutes that are well worth your while.

CAPE-based propolis extract (BIO30) suppresses the growth of human neurofibromatosis tumor xenografts in mice

Neurofibromatosis (NF) is a genetic disorder in which the nerve tissue grows tumors (neurofibromas) that may be benign and may cause serious damage by compressing nerves and other tissues.

This study demonstrated that BIO30 New Zealand Propolis, which is high in Caffeic acid phenethyl ester (CAPE), completely supressed the growth of human Nerofibromatosis (NF1) tumors in mice and caused almost complete regression of human NF2 tumors in mice.

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The direct PAK1 inhibitor, TAT-PAK18, blocks preferentially the growth of human ovarian cancer cell lines in which PAK1 is abnormally activated by autophosphorylation at Thr 423

In this research study, it was demonstrated that an ovarian cancer cell line was a PAK1-dependent cancer, as are more than 70% of all human cancers including breast, prostate, pancreatic, colon, gastric, lung, cervical, and thyroid as well as hepatoma, glioma, melanoma, MM (multiple myeloma) and NF (neurofibromatosis) tumors.

Caffeic acid phenethyl ester (CAPE), present in BIO30 New Zealand Propolis, is recognised as being a PAK-1 inhibitor.

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Effective neurofibromatosis therapeutics blocking the oncogenic kinase PAK1

In this review, Professor Hiroshi Maruta, NF/TSC Cure Org., Melbourne, Australia, summarises his view on both the pharmaceutical and natural products available that are known to inhibit PAK1 which is essential for the growth of both Neurofibromatosis Type 1 (NF1) and Type 2 (NF2) tumors.

 BIO30 New Zealand Propolis, high in Caffeic acid phenethyl ester (CAPE), is one of the natural products available that Prof Maruta reviews.

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Cancer Research Trials with BIO30 New Zealand Propolis

Professor Hiroshi Maruta has been a leading figure in several cancer research trials using BIO30 Propolis.

Professor Maruta has spent more than 35 years researching cancer and has worked for the last 20 years at the Ludwig Cancer Research Institute at the Royal Melbourne Hospital in Australia.

His work with CAPE was conducted while he was at the University Medical Hospital, Eppendorf, Germany.

Professor Maruta led research into the use of caffeic acid phenethyl ester (CAPE) in BIO30 Propolis in the treatment of neurofibromatosis (NF).

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Propolis Stops Prostate Cancer in Mice

Researchers at the University of Chicago found that a compound made in honeybee hives seems to stop the spread of prostate cancer cells in mice.

The compound, called caffeic acid phenethyl ester or CAPE, is made from propolis, the resin honeybees use to patch holes in their hives. The product has been known and used for centuries as a natural remedy for teeth and skin, as well as a defense against viruses and bacteria.

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Propolis for Hive Immunity

This article presents new research about honeybees utilising propolis not just to sterilise their hives, but also to induce a type of 'social immunity' providing protection to the entire colony.

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CAPE in Propolis Suppresses Growth of Prostate Cancer Cells

Caffeic Acid Phenethyl Ester Suppresses the Proliferation of Human Prostate Cancer Cells through Inhibition of p70S6K and Akt Signaling Networks.

The University of ChicagoAbstract

Caffeic acid phenethyl ester (CAPE) is a bioactive component derived from honeybee hive propolis. CAPE has been shown to have antimitogenic, anticarcinogenic, and other beneficial medicinal properties. Many of its effects have been shown to be mediated through its inhibition of NF-κB signaling pathways.

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